No Antibodies Required For Immunity Against Some Viruses
March 27, 2012 A new study turns the well established theory that antibodies are required for antiviral immunity upside down and reveals that an unexpected partnership between the specific and non-specific divisions of the immune system is critical for fighting some types of viral infections. The research, published online in the journal Immunity by Cell Press, may lead to a new understanding of the best way to help protect those exposed to potentially lethal viruses, such as the rabies virus.
The immune system has two main branches, innate immunity and adaptive immunity. Innate immunity is a first line of defense that relies on cells and mechanisms that provide non-specific immunity. The more sophisticated adaptive immunity, which counts antibody-producing B cells as part of its arsenal, is thought to play a major role in the specific response to viral infections in mammals. However, adaptive immune responses require time to become fully mobilized.
"Mice infected with vesicular stomatitis virus (VSV) can suffer fatal invasion of the central nervous system even when they have a high concentration of anti-VSV antibodies in their system," explains senior study author, Dr. Ulrich H. von Andrian, from Harvard Medical School. "This observation led us to revisit the contribution of adaptive immune responses to survival following VSV infection."
Read More:
