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Entries in Health (619)

Wednesday
Nov282012

We're Eating What? The Drugstore in U.S. Meat

Food consumers seldom hear about the drugs oestradiol-17, zeranol, trenbolone acetate and melengestrol acetate and the names are certainly not on meat labels. But those synthetic growth hormones are central to U.S. meat production, especially beef, and the reason Europe has banned a lot of U.S. meat since 1989.

Zeranol, widely used as a growth promoter in the U.S. beef industry, is known for its "ability to stimulate growth and proliferation of human breast tumor cells" like the "known carcinogen diethylstilbestrol (DES)," says the Breast Cancer Fund, a group dedicated to identifying and eliminating environmental causes of breast cancer.   Zeranol may "play a critical role in mammary tumorigenesis" and "be a risk factor for breast cancer," agrees a recent paper from the College of Food Science and Nutritional Engineering at China Agricultural University in Beijing.

Why is such a drug, that requires "Appropriate Personal Protective Equipment" for use-- "laboratory coat, gloves, safety glasses and mask"--routinely used in U.S. meat production and not even labeled?

Melengestrol acetate, a synthetic progestin put in feed, is 30 times as active as natural progesterone, says the European Commission (EC) and trenbolone acetate, a synthetic androgen, is several times more active than testosterone. Trenbolone acetate is administered as ear implants commonly seen at livestock operations. Operators say the implants and the ears are removed from the human food supply at the slaughterhouse. Do they become feed for other animals?

Why does the European Commission ban meat made with such chemicals?   "There is an association between steroid hormones and certain cancers and an indication that meat consumption is possibly associated with increased risks of breast cancer and prostate cancer," says the EC's Committee on Veterinary Measures. "The highest rates of breast cancer are observed in North America, where hormone-treated meat consumption is highest in the world," it says, adding that the same statistics apply to prostate cancer.

In fact, Kwang Hwa, Korea, has only seven new cases of breast cancer per 100,000 people, says the EC report, whereas non-Hispanic Caucasians in Los Angeles have 103 new cases per 100,000 people. The breast cancer rate also increases among immigrant groups when they move to the U.S., says the report, suggesting causes are not genetic but environmental. In the overarching search for a "cure," is the "cause" of a lot of possible U.S. breast cancer overlooked?

Another growth drug used in U.S. beef, pork and turkey--yes turkey--is ractopamine an asthma-like drug called a beta agonist. Like growth hormones, ractopamine lets livestock operators produce more weight more quickly from their animals. Ractopamine was integrated into the food supply under reporters' and consumers' radar more than ten years ago. It became a favorite on U.S. farms when its ability to increase muscle by "repartitioning" nutrients and slowing protein degradation was discovered in a laboratory.

Unlike other veterinary drugs used in U.S. meat that are withdrawn before slaughter (or thrown away as ears) ractopamine is begun in the days before slaughter and never withdrawn. It is given to cattle for their last 28 to 42 days, to pigs for their last 28 days, and to turkeys for their last seven to 14 days. Marketed as Paylean for pigs, as Optaflexx for cattle, and as Topmax for turkeys, ractopamine is not just banned in Europe, it is banned in 160 countries.

Public health officials and livestock specialists are increasingly questioning the drug's wide and often clandestine use. "Ractopamine usage benefits producers, but not consumers. It is bad for animal welfare and has some bad effects on humans," said Donald Broom, a professor at the University of Cambridge's department of veterinary medicine, at a forum on the topic in Taipei earlier this year.

In China, the Sichuan Pork Trade Chamber of Commerce reported that more than 1,700 people have been "poisoned" from eating   Paylean-fed pigs since 1998 in 2007, it seized U.S. pork for its ractopamine residues.

Thanks to the black hand of Big Meat on USDA and FDA policies, the drugstore in U.S. meat is largely hidden from food consumers. So are the health effects of the cheap, ubiquitous and unwholesome meat. END

http://www.opednews.com/articles/We-re-Eating-What-The-Dru-by-Martha-Rosenberg-121127-485.html

 

Tuesday
Nov272012

More Research Shows Positivity Adds Years to Life

A multitude of factors contribute to longevity, like diet and activity level. Research is packing weight to evidence that positivity does more than make life more pleasant, however; it makes it longer.

A Yale School of Public Health study found older individuals with positive attitudes about aging experienced a lower likelihood of suffering from—or a greater chance of recovering from—disabilities and sickness.

Positive or Negative Associations with Age Add (or Subtract) Years of Life

Every month, researchers interviewed the same 598 people of at least 70 years of age (the average age being 79) who, at the beginning of the study, had no disabilities. (Being free of disabilities constituted four activities for this study: bathing, dressing, moving from a chair, and walking.)

Participants were asked for five terms or phrases they believed described the elderly, which the researchers then graphed on a five-point scale. In example, the negative descriptor, “decrepit,” scored 1 on the scale, while a positive descriptor like “spry” scored a 5. This continued for up to 129 months in addition to each participant filling out home-based assessments every 18 months for 10 years.

Compiled evidence suggested that positive associations with aging allowed people to live more independently in later years.

Thoughts can Help Reduce and Reverse Health Risks

“This result suggests that how the old view their aging process could have an effect on how they experience it,” says lead researcher Becca R. Levy. “In previous studies, we have found that older individuals with positive age stereotypes tend to show lower cardiovascular response to stress and they tend to engage in healthier activities, which may help to explain our current findings.”

This isn’t Levy’s first foray into the subject; she published another study in 2002 showing that people with positive outlooks on aging lived on average 7.6 years longer than their more pessimistic counterparts. Earlier this year, the journal Psychosomatic Medicine published a study indicating that a positive outlook could help reduce and even reverse increasing health risks inherent in older age.

Evidence Piling Up

The idea of the metaphysical influencing the physical is nothing new but has until recently been assumed to be the stuff of hocus pocus and quackery. It seems hardly like the National Institutes of Health to throw $9.5 million on quackery, though. The study in question involved 756 participants in three studies showing the positive thoughts and health affirmations helped create behavioral changes and physical transformation.

Even if you’re not convinced, what’s the hurt in a little smile?

http://naturalsociety.com/research-positivity-adds-years-to-life/?utm_source=Natural+Society&utm_campaign=ffa1d34c4d-Email+37%3A+11%2F23%2F2012&utm_medium=email

Monday
Nov262012

Meditation fights flu better than pills

Meditation could be very useful at preventing winter ailments than popping vitamins or herbal remedies as "insurance policy" to stave off colds and flu, a new study has revealed.

According to a study from the University of Wisconsin-Madison, adults who meditated or did moderately intense exercise, such as a brisk walk, for eight weeks suffered fewer colds than those who did nothing, the Daily Mailreported.

 

Previous research has found that mindfulness meditation may improve mood, decrease stress, and boost immune function.

The 149 people in this new study were divided into three groups. One performed mindful meditation, a type of meditation that essentially involves focusing the mind on the present.

Another group jogged regularly for eight weeks while the third group did nothing.

The researchers then followed the health of the volunteers through the winter from September to May, although they didn't check whether or not people carried on exercising or meditating after the eight-week period.

The participants were observed for cold and flu symptoms such as a runny nose, stuffiness, sneezing, and sore throat. Nasal wash samples were collected and analysed three days after the symptoms began.

The study, found that meditators missed 76 per cent fewer days of work from September through to May than those who did nothing. Those who had exercised missed 48 per cent fewer days during this period.

In addition, mindful meditation can reduce the duration or severity of acute respiratory infections such by up to 50 per cent, and exercise by up to 40 per cent.

According to the website Scientific America, those who had exercised or meditated suffered for an average of five days; colds of participants in the control group lasted eight.

In addition, tests confirmed that the self-reported length of colds correlated with the level of antibodies in the body, which indicate the presence of a virus.

"Nothing has previously been shown to prevent acute respiratory infections," lead author Dr Bruce Barrett, a family medicine doctor and associate professor at the University said.

"A lot of previous information suggested that meditation and exercise might have prevention benefits, but no high-quality, randomised trial had been done.

Wednesday
Nov212012

GM corn variety 'cannot be regarded as safe': Author of study linking it to cancer hits back at critics

The team of researchers who caused uproar when they claimed a variety of genetically modified corn causes cancer has insisted the crop 'cannot be regarded as safe'.

Leading scientists lined up to condemn the study after it was published two months ago, saying it lacked scientific rigour and had made a series of basic errors.

Russia banned the import of the corn and a group of six French scientific institutions carried out an investigation which accused the study authors of playing on public fears to hype their own reputations.

But French scientist Dr Gilles-Eric Séralini and his colleagues have now hit back maintaining the safety of the NK603 variety of GM corn remains unproven.

They accused many of their critics of lacking credibility because of links to the GM industry and said much of the criticism was led by 'plant biologists, some developing patents on GMOs, and from Monsanto Company owning these products'.

 Refusing to give in to demands to withdraw their study, they said their findings represented 'the most detailed test' of genetically modified crops that are ' independent from the biotech and pesticide companies' which develop them.

They said in their rebuttal, published as a letter to the journal Food and Chemical Toxicology, that unlike many other scientists involved in researching GM foods they were free from industry influence because they had no intention of 'commercialising a new product'.

It was also pointed out by the team that the research represented a 'first step' rather than a final conclusion about the potential impacts of NK603 corn and that further experiments may be able to establish its safety.

For their original study they carried out experiments on rats and concluded that the GM corn, developed by US biotech company Monsanto, increased the risks of breast cancer and liver and kidney damage.

Experiments carried out by the team also suggested that tiny quantities of the widely available weedkiller Roundup, also developed by Monsanto, was also associated with an increased risk of cancer.

The experiments were carried out over two years whereas, they pointed out, biotech companies have usually based claims that their GM products are safe after feeding new varieties to rats for 90 days.

After publication of the study, in the peer reviewed Food and Chemical Toxicology, a dozen senior scientists signed a letter to the journalsaying it should never have been published.

GM FOOD REGULATION

GM food and feed is strictly regulated within the EU.

Labels must indicate to consumers when GM ingredients are included in food

All products that are GM or include GM ingredients must meet traceability rules so that all retailers are able to identify their suppliers.

Risk assessments for all new GM products are carried out by the European Food Safety Authority before they can be sold in Europe

'This study does not provide sound evidence to support its claims. Indeed, the flaws in the study are so obvious that the paper should never have passed review,' they wrote.

'This appears to be a case of blatant misrepresentation and misinterpretation of data to advance an anti-GMO agenda by an investigator with a clear vested interest.'

The European Food Safety Authority (EFSA) ordered a French University to carry out a review of the research while in Russia the Institute of Nutrition was asked to conduct a similar exercise.

Monsanto said in a statement in September: 'Based on our initial review, we do not believe the study presents information that would justify any change in EFSA’s views on the safety of genetically modified corn products or alter their approval status for genetically modified imports.'

http://www.dailymail.co.uk/sciencetech/article-2236219/GM-corn-variety-regarded-safe-Dr-Gilles-Eric-S-ralini-hits-critics.html

Tuesday
Nov202012

The Great Mexican Maize Massacre

Agribusiness giants Monsanto, DuPont and Dow are plotting the boldest coup of a global food crop in history. If their requests to allow a massive commercial planting of genetically modified (GM) maize are approved in the next two weeks by the government of outgoing president Felipe Calderón, this parting gift to the gene giants will amount to a knife in the heart of the center of origin and diversity for maize. The consequences will be grave – and global. With the approvals and December planting deadlines looming, social movements and civil society organizations have called for an end to all GM maize in Mexico. Mexico’s Union of Concerned Scientists (UCCS) has called on the Mexican government to stop the processing of any application for open-field release of GM maize in Mexico.[1] ETC Group joins these calls, and appeals to the UN Food and Agriculture Organization (FAO) and to the UN Convention on Biological Diversity (CBD) – intergovernmental bodies mandated to suppo
rt food
security and biodiversity – to take immediate action.

Outrage and alarm rang out through Mexico when the world's two largest commercial seed companies, Monsanto and DuPont (whose seed business is known as DuPont Pioneer Hi-Bred International, Inc.), and Dow AgroSciences (the world's 8th largest seed company) applied to the government for the planting of 2,500,000 hectares (more than 6 million acres) of transgenic maize in Mexico.[2] The land area is massive – about the size of El Salvador. Scientists have identified thousands of peasant varieties of maize, making Mexico the global repository of maize genetic diversity. If the agribusiness applications are approved, it will mark the world's first commercial-scale planting of genetically modified varieties of a major food crop in its center of origin.

"If Mexico’s government allows this crime of historic significance to happen, GMOs will soon be in the food of the entire Mexican population, and genetic contamination of Mexican peasant varieties will be inevitable. We are talking about damaging more than 7,000 years of indigenous and peasant work that created maize – one of the world's three most widely eaten crops," said Verónica Villa from ETC’s Mexico office. "As if this weren't bad enough, the companies want to plant Monsanto's herbicide-tolerant maize [Mon603] on more than 1,400,000 hectares. This is the same type of GM maize that has been linked to cancer in rats according to a recently published peer-reviewed study."[3]

To read the full release, please download the PDF.
http://www.etcgroup.org/sites/www.etcgroup.org/files/ETCNR-GMmaizefinal15Nov2012_links_1.pdf

[1] UCCS (Unión de Científicos Comprometidos con la Sociedad), "Statement: Call to action vs the planting of GMO corn in open field situations in Mexico," November 2012, available online: http://www.uccs.mx/doc/g/planting-gmo-corn.

[2] The list of commercial applications for environmental release of GMOs is available here: http://www.senasica.gob.mx/?id=4443. (In Mexico, DuPont Pioneer Hi-Bred International, Inc., is known by the name PHI México.)

[3] Gilles-Eric Séralini et al., "Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize," Food and Chemical Toxicology, Volume 50, Issue 11, November 2012, pp. 4221–4231. See also, John Vidal, "Study linking GM maize to cancer must be taken seriously by regulators," The Guardian, 28 September 2012, available online: http://www.guardian.co.uk/environment/2012/sep/28/study-gm-maize-cancer.

http://www.etcgroup.org/content/great-mexican-maize-massacre

Monday
Nov192012

Phthalates wreak havoc on your health

Phthalates, chemicals used to soften plastics, are found in many personal care products such as hair sprays, perfumes, nail polish, sunscreens and lotions. They are also used in medical devices, on timed release pills (where they are often part of the coating), in children's toys and plastic food containers as well as in such products as floor and wall coverings. The new car smell, which makes owners proud, is due in part to phthalates which can escape from the plastic dashboard after sun exposure and leave a nasty coating on the inside of the windshield. A 2000 study published in the journal Environmental Health Perspectives found widespread phthalate exposure throughout U.S. society, with the highest levels in women of childbearing age; a troubling finding since these chemicals are known endocrine disruptors. Subsequent studies have linked phthalate exposure and a variety of health conditions making their widespread use a serious public health concern.

Women's health

A 2012 study conducted by researchers at Brigham and Women's Hospital examined urine samples from 2,350 women from around the United States looking for concentrations of phthalates. Their results showed striking correlations between phthalate levels and diabetes. Those with the highest levels of two common phthalates were also almost twice as likely to develop diabetes as were those with the lowest levels.

Yet another phthalate study was conducted in 2012, by scientists at Washington University's School of Medicine. This research involved evaluating phthalate levels in the blood and urine of 5,700 women. Findings showed that on average, women with the highest levels of phthalatesexperienced menopause 2.3 years earlier than those with lower levels, exposing them that much earlier to serious menopause related health risks such as heart disease and osteoporosis.

Phthalates and sexual development in children

Studies of young girls in Puerto Rico have found high rates of premature thelarche, which is breast development before the age of eight, and often as young as two. In a study published in 2000, researchers compared 41 girls suffering from premature thelarche with 31 who were not. They found seven times the level of phthalates in the former group compared to the controls, a significant difference.

More recently, studies of male fetal development evaluated phthalate exposure in mothers in relation to play behavior. The urine from women near their 28th month of pregnancy was analyzed for phthalates. Mothers then answered a questionnaire about their child's play behavior and results were adjusted for differences in parental attitudes about sex specific play. Scores for masculine play behavior were lower in boys whose mothers had high levels of phthalates in their urine. Researchers suggest that phthalates may lower testosterone production during a critical time of male brain development.

Phthalates may contribute to attention deficit

Phthalates may also contribute to well documented increases in attention deficit disorder. Researchers in Korea compared phthalate levels in the urine of 261 school aged children between eight and 11 years old with symptoms of ADHD. Results confirmed a strong positive correlation between the two.

While none of these studies proves cause and effect, they suggest the need for further research on this critical topic, along with careful avoidance of phthalates whenever possible.

http://www.naturalnews.com/038010_phthalates_health_children.html

Friday
Nov162012

Does Sugar Kill? How the Sugar Industry Hid the Toxic Truth

ON A BRISK SPRING Tuesday in 1976, a pair of executives from the Sugar Association stepped up to the podium of a Chicago ballroom to accept [5] the Oscar of the public relations world, the Silver Anvil [6] award for excellence in "the forging of public opinion. [7]" The trade group had recently pulled off one of the greatest turnarounds in PR history. For nearly a decade, the sugar industry had been buffeted by crisis after crisis as the media and the public soured on sugar and scientists began to view it as a likely cause of obesity, diabetes, and heart disease. Industry ads claiming that eating sugar helped you lose weight had been called out [8] by the Federal Trade Commission, and the Food and Drug Administration had launched a review [9] of whether sugar was even safe to eat. Consumption had declined 12 percent in just two years, and producers could see where that trend might lead. As John "JW" Tatem Jr. and Jack O'Connell Jr., the Sugar Association's president and director of public relations, posed that day with their trophies, their smiles only hinted at the coup they'd just pulled off.

Their winning campaign, crafted with the help of the prestigious public relations firm Carl Byoir & Associates, had been prompted by a poll [10] showing that consumers had come to see sugar as fattening, and that most doctors suspected it might exacerbate, if not cause, heart disease and diabetes. With an initial annual budget of nearly $800,000 ($3.4 million today) collected from the makers of Dixie Crystals, Domino, C&H, Great Western, and other sugar brands, the association recruited a stable of medical and nutritional professionals to allay the public's fears, brought snack and beverage companies into the fold, and bankrolled scientific papers that contributed to a "highly supportive" FDA ruling, which, the Silver Anvil application boasted, made it "unlikely that sugar will be subject to legislative restriction in coming years."

The story of sugar, as Tatem told it, was one of a harmless product under attack by "opportunists dedicated to exploiting the consuming public. [11]" Over the subsequent decades, it would be transformed from what the New York Times in 1977 had deemed "a villain in disguise [12]" into a nutrient so seemingly innocuous that even the American Heart Association and the American Diabetes Association approved it as part of a healthy diet. Research on the suspected links between sugar and chronic disease largely ground to a halt by the late 1980s, and scientists came to view such pursuits as a career dead end. So effective were the Sugar Association's efforts that, to this day, no consensus exists about sugar's potential dangers. The industry's PR campaign corresponded roughly with a significant rise in Americans' consumption of "caloric sweeteners, [13]" including table sugar (sucrose) and high-fructose corn syrup (HFCS). This increase was accompanied, in turn, by a surge in the chronic diseases increasingly linked to sugar. Since 1970, obesity rates [14] in the United States have more than doubled, while the incidence of diabetes [15] has more than tripled. (The chart below uses sugar "availability" numbers rather than the USDA's speculative new consumption figures [16].)

 

 

 

Precisely how did the sugar industry engineer its turnaround? The answer is found in more than 1,500 pages of internal memos, letters, and company board reports we discovered buried in the archives [17] of now-defunct sugar companies as well as in the recently released papers of deceased researchers and consultants who played key roles in the industry's strategy. They show how Big Sugar used Big Tobacco-style tactics to ensure that government agencies would dismiss troubling health claims against their products. Compared to the tobacco companies, which knew for a fact that their wares were deadly and spent billions of dollars trying to cover up that reality, the sugar industry had a relatively easy task. With the jury still out on sugar's health effects, producers simply needed to make sure that the uncertainty lingered. But the goal was the same: to safeguard sales by creating a body of evidence companies could deploy to counter any unfavorable research.

This decades-long effort to stack the scientific deck is why, today, the USDA's dietary guidelines [18] only speak of sugar in vague generalities. ("Reduce the intake of calories from solid fats and added sugars.") It's why the FDA insists that sugar is "generally recognized as safe [19]" despite considerable evidence suggesting otherwise. It's why some scientists' urgent calls for regulation of sugary products have been dead on arrival, and it's why—absent any federal leadership—New York City Mayor Michael Bloomberg felt compelled to propose a ban on oversized sugary drinks [20] that passed in September.

In fact, a growing body of research suggests that sugar and its nearly chemically identical cousin, HFCS, may very well cause diseases that kill hundreds of thousands of Americans every year, and that these chronic conditions would be far less prevalent if we significantly dialed back our consumption of added sugars. Robert Lustig, a leading authority on pediatric obesity at the University of California-San Francisco (whose arguments Gary explored in a 2011 New York Times Magazine cover story [21]), made this case last February in the prestigious journal Nature. In an article titled "The Toxic Truth About Sugar, [22]" Lustig and two colleagues observed that sucrose and HFCS are addictive in much the same way as cigarettes and alcohol, and that overconsumption of them is driving worldwide epidemics of obesity and type 2 diabetes (the type associated with obesity). Sugar-related diseases are costing America around $150 billion a year, the authors estimated, so federal health officials need to step up and consider regulating the stuff.

 

The Sugar Association dusted off [23] what has become its stock response: The Lustig paper, it said, "lacks the scientific evidence or consensus" to support its claims, and its authors were irresponsible not to point out that the full body of science "is inconclusive at best." This inconclusiveness, of course, is precisely what the Sugar Association has worked so assiduously to maintain. "In confronting our critics,"Tatem explained [24] to his board of directors back in 1976, "we try never to lose sight of the fact that no confirmed scientific evidence links sugar to the death-dealing diseases. This crucial point is the lifeblood of the association."

THE SUGAR ASSOCIATION'S earliest incarnation [25] dates back to 1943, when growers and refiners created the Sugar Research Foundation to counter World War II sugar-rationing propaganda [26]—"How Much Sugar Do You Need? None!" declared one government pamphlet. In 1947, producers rechristened their group the Sugar Association and launched a new PR division, Sugar Information Inc., which before long was touting sugar [27] as a "sensible new approach to weight control." In 1968, in the hope of enlisting foreign sugar companies to help defray costs, the Sugar Association spun off its research division as the International Sugar Research Foundation. "Misconceptions concerning the causes of tooth decay, diabetes, and heart problems exist on a worldwide basis," explained a 1969 ISRF recruiting brochure [28].

As early as 1962, internal Sugar Association memos had acknowledged the potential links between sugar and chronic diseases, but at the time sugar executives had a more pressing problem: Weight-conscious Americans were switching in droves to diet sodas—particularly Diet Rite and Tab—sweetened with cyclamate and saccharin. From 1963 through 1968, diet soda's share of the soft-drink market shot from 4 percent to 15 percent. "A dollar's worth of sugar," ISRF vice president and research director John Hickson warned in an internal review, "could be replaced with a dime's worth" of sugar alternatives. "If anyone can undersell you nine cents out of 10," Hickson told the New York Times [29] in 1969, "you'd better find some brickbat you can throw at him."

 

By then, the sugar industry had doled out more than $600,000 (about $4 million today) to study every conceivable harmful effect of cyclamate sweeteners, which are still sold around the world under names like Sugar Twin and Sucaryl. In 1969, the FDA banned cyclamates in the United States based on a study suggesting they could cause bladder cancer in rats. Not long after, Hickson left the ISRF to work for the Cigar Research Council. He was described in a confidential tobacco industry memo [30] as a "supreme scientific politician who had been successful in condemning cyclamates, on behalf of the [sugar industry], on somewhat shaky evidence." It later emerged that the evidence suggesting that cyclamates caused cancer in rodents was not relevant to humans [31], but by then the case was officially closed. In 1977, saccharin, too, was nearly banned on the basis of animal results that would turn out to be meaningless in people.

Meanwhile, researchers had been reporting that blood lipids—cholesterol and triglycerides in particular—were a risk factor in heart disease. Some people had high cholesterol but normal triglycerides, prompting health experts to recommend that they avoid animal fats. Other people were deemed "carbohydrate sensitive," with normal cholesterol but markedly increased triglyceride levels. In these individuals, even moderate sugar consumption could cause a spike in triglycerides. John Yudkin, the United Kingdom's leading nutritionist, wasmaking headlines [32] with claims that sugar, not fat, was the primary cause of heart disease.

In 1967, the Sugar Association's research division began considering "the rising tide of implications of sucrose in atherosclerosis." Before long, according to a confidential 1970 review of industry-funded studies, the newly formed ISRF was spending 10 percent of its research budget on the link between diet and heart disease. Hickson, the ISRF's vice president, urged his member corporations to keep the results of the review under wraps. Of particular concern was the work of a University of Pennsylvania researcher on "sucrose sensitivity," which sugar executives feared was "likely to reveal evidence of harmful effects. [33]" One ISRF consultant recommended [34] that sugar companies get to the truth of the matter by sponsoring a full-on study. In what would become a pattern, the ISRF opted not to follow his advice. Another ISRF-sponsored study, by biochemist Walter Pover of the University of Birmingham, in England, had uncovered a possible mechanism to explain how sugar raises triglyceride levels. Pover believed he was on the verge of demonstrating this mechanism "conclusively" and that 18 more weeks of work would nail it down. But instead of providing the funds, the ISRF nixed the project, assessing its value as "nil."

 

The industry followed a similar strategy when it came to diabetes. By 1973, links between sugar, diabetes, and heart disease were sufficiently troubling that Sen. George McGovern of South Dakota convened a hearing of his Select Committee on Nutrition and Human Needs to address the issue. An international panel of experts—including Yudkin and Walter Mertz, head of the Human Nutrition Institute at the Department of Agriculture—testified that variations in sugar consumption were the best explanation for the differences in diabetes rates between populations, and that research by the USDA and others supported the notion that eating too much sugar promotes dramatic population-wide increases in the disease. One panelist, South African diabetes specialist George Campbell, suggested that anything more than 70 pounds per person per year—about half of what is sold in America today—would spark epidemics.

In the face of such hostile news from independent scientists, the ISRF hosted its own conference the following March, focusing exclusively on the work of researchers who were skeptical of a sugar/diabetes connection. "All those present agreed that a large amount of research is still necessary before a firm conclusion can be arrived at," according to aconference review [35] published in a prominent diabetes journal. In 1975, the foundation reconvened in Montreal to discuss research priorities with its consulting scientists. Sales were sinking, Tatem reminded the gathered sugar execs, and a major factor was "the impact of consumer advocates who link sugar consumption with certain diseases."

Following the Montreal conference, the ISRF disseminated a memo [36] quoting Errol Marliss, a University of Toronto diabetes specialist, recommending that the industry pursue "well-designed research programs" to establish sugar's role in the course of diabetes and other diseases. "Such research programs might produce an answer that sucrose is bad in certain individuals," he warned. But the studies "should be undertaken in a sufficiently comprehensive way as to produce results. A gesture rather than full support is unlikely to produce the sought-after answers."

 

A gesture, however, is what the industry would offer. Rather than approve a serious investigation of the purported links between sucrose and disease, American sugar companiesquit supporting [37] the ISRF's research projects. Instead, via the Sugar Association proper, they would spend roughly $655,000 between 1975 and 1980 on 17 studies [38] designed, as internal documents put it, "to maintain research as a main prop of the industry's defense. [39]" Each proposal was vetted by a panel [40] of industry-friendly scientists and a second committee [41] staffed by representatives from sugar companies and "contributing research members [42]" such as Coca-Cola, Hershey's, General Mills, and Nabisco. Most of the cash was awarded to researchers whose studies seemed explicitly designed to exonerate sugar. One even proposed to explore whether sugar could be shown to boost serotonin levels in rats' brains, and thus "prove of therapeutic value, as in the relief of depression," an internal document noted [43].

At best, the studies seemed a token effort. Harvard Medical School professor Ron Arky, for example, received money from the Sugar Association to determine whether sucrose has a different effect on blood sugar and other diabetes indicators if eaten alongside complex carbohydrates like pectin and psyllium. The project went nowhere, Arky told us recently. But the Sugar Association "didn't care."

In short, rather than do definitive research to learn the truth about its product, good or bad, the association stuck to a PR scheme designed to "establish with the broadest possible audience—virtually everyone is a consumer—the safety of sugar as a food." One of its first acts was to establish a Food & Nutrition Advisory Council [44] consisting of a half-dozen physicians and two dentists willing to defend sugar's place in a healthy diet, and set aside roughly $60,000 per year (more than $220,000 today) to cover its cost [45].

Working to the industry's recruiting advantage was the rising notion that cholesterol and dietary fat—especially saturated fat—were the likely causes of heart disease. (Tatem even suggested, in a letter to the Times Magazine [46], that some "sugar critics" were motivated merely by wanting "to keep the heat off saturated fats.") This was the brainchild of nutritionist Ancel Keys, whose University of Minnesota laboratory had received financial support from the sugar industry as early as 1944. From the 1950s through the 1980s, Keys remained the most outspoken proponent of the fat hypothesis, often clashing publicly with Yudkin, the most vocal supporter of the sugar hypothesis—the two men "shared a good deal of loathing," recalled one of Yudkin's colleagues.

So when the Sugar Association needed a heart disease expert for its Food & Nutrition Advisory Council, it approached Francisco Grande, one of Keys' closest colleagues. Another panelist was University of Oregon nutritionist William Connor, the leading purveyor of the notion that it is dietary cholesterol that causes heart disease. As its top diabetes expert, the industry recruitedEdwin Bierman [47] of the University of Washington, who believed that diabetics need not pay strict attention to their sugar intake so long as they maintained a healthy weight by burning off the calories they consumed. Bierman also professed an apparently unconditional faith that it was dietary fat (and being fat) that caused heart disease, with sugar having no meaningful effect.

It is hard to overestimate Bierman's role in shifting the diabetes conversation away from sugar. It was primarily Bierman who convinced the American Diabetes Association to liberalize the amount of carbohydrates (including sugar) it recommended in the diets of diabetics, and focus more on urging diabetics to lower their fat intake, since diabetics are particularly likely to die from heart disease. Bierman also presented industry-funded studies when he coauthored a section on potential causes for a National Commission on Diabetes report in 1976; the document influences the federal diabetes research agenda to this day. Some researchers, he acknowledged, had "argued eloquently" that consumption of refined carbohydrates (such as sugar) is a precipitating factor in diabetes. But then Bierman cited five studies—two of them bankrolled by the ISRF—that were "inconsistent" with that hypothesis. "A review of all available laboratory and epidemiologic evidence," he concluded, "suggests that the most important dietary factor in increasing the risk of diabetes is total calorie intake, irrespective of source."

 

The point man on the industry's food and nutrition panel wasFrederick Stare [48], founder and chairman of the department of nutrition at the Harvard School of Public Health. Stare and his department had a long history of ties to Big Sugar. An ISRF internal research review credited the sugar industry with funding some 30 papers in his department from 1952 through 1956 alone. In 1960, the department broke ground on a new $5 million building funded largely by private donations, including a $1 million gift from General Foods, the maker of Kool-Aid and Tang.

By the early 1970s, Stare ranked among the industry's most reliable advocates, testifying in Congress about the wholesomeness of sugar even as his department kept raking in funding from sugar producers and food and beverage giants such as Carnation, Coca-Cola, Gerber, Kellogg, and Oscar Mayer. His name also appears in tobacco documents, which show that he procured [49] industry funding for a study [50] aimed at exonerating cigarettes as a cause of heart disease.

The first act of the Food & Nutrition Advisory Council was to compile "Sugar in the Diet of Man," an 88-page white paper edited by Stare and published in 1975 to "organize existing scientific facts concerning sugar." It was a compilation of historical evidence and arguments that sugar companies could use to counter the claims of Yudkin, Stare's Harvard colleague Jean Mayer, and other researchers whom Tatem called "enemies of sugar. [51]" The document was sent to reporters—the Sugar Association circulated 25,000 copies—along with a press release [52] headlined "Scientists dispel sugar fears." The report neglected to mention that it was funded by the sugar industry, but internal documents confirm that it was [53].

 

The Sugar Association also relied on Stare to take its message to the people: "Place Dr. Stare on the AM America Show" and "Do a 3 ½ minute interview with Dr. Stare for 200 radio stations," note the association's meeting minutes. Using Stare as a proxy, internal documents explained [54], would help the association "make friends with the networks" and "keep the sugar industry in the background." By the time Stare's copious conflicts of interest were finally revealed—in "Professors on the Take, [55]" a 1976 exposé by the Center for Science in the Public Interest—Big Sugar no longer needed his assistance. The industry could turn to an FDA document to continue where he'd left off.

While Stare and his colleagues had been drafting "Sugar in the Diet of Man," the FDA was launching its first review of whether sugar was, in the official jargon, generally recognized as safe (GRAS), part of a series of food-additive reviews [56] the Nixon administration had requested of the agency. The FDA subcontracted the task to the Federation of American Societies of Experimental Biology, which created an 11-member committee to vet hundreds of food additives from acacia to zinc sulfate. While the mission of the GRAS committee was to conduct unbiased reviews of the existing science for each additive, it was led by biochemist George W. Irving Jr., who had previously served two years as chairman of the scientific advisory board of the International Sugar Research Foundation. Industry documents show that another committee member, Samuel Fomon, had received sugar-industry funding for three of the five years prior to the sugar review.

The FDA's instructions were clear: To label a substance as a potential health hazard, there had to be "credible evidence of, or reasonable grounds to suspect, adverse biological effects"—which certainly existed for sugar at the time. But the GRAS committee's review would depend heavily on "Sugar in the Diet of Man" and other work by its authors. In the section on heart disease, committee members cited 14 studies whose results were "conflicting," but 6 of those bore industry fingerprints, including Francisco Grande's chapter from "Sugar in the Diet of Man" and 5 others that came from Grande's lab or were otherwise funded by the sugar industry.

 

The diabetes chapter of the review acknowledged studies suggesting that "long term consumption of sucrose can result in a functional change in the capacity to metabolize carbohydrates and thus lead to diabetes mellitus," but it went on to cite five reports contradicting that notion. All had industry ties, and three were authored by Ed Bierman, including his chapter in "Sugar in the Diet of Man."

In January 1976, the GRAS committee published its preliminary conclusions, noting that while sugar probably contributed to tooth decay, it was not a "hazard to the public." The draft review dismissed the diabetes link as "circumstantial" and called the connection to cardiovascular disease "less than clear," with fat playing a greater role. The only cautionary note, besides cavities, was that all bets were off if sugar consumption were to increase significantly. The committee then thanked the Sugar Association for contributing "information and data." (Tatem would later remark [57] that while he was "proud of the credit line...we would probably be better off without it.")

The committee's perspective was shared by many researchers, but certainly not all. For a public hearing on the draft review, scientists from the USDA's Carbohydrate Nutrition Laboratory submitted what they considered "abundant evidence that sucrose is one of the dietary factors responsible for obesity, diabetes, and heart disease." As they later explained [58]in the American Journal of Clinical Nutrition, some portion of the public—perhaps 15 million Americans at that time—clearly could not tolerate a diet rich in sugar and other carbohydrates. Sugar consumption, they said, should come down by "a minimum of 60 percent," and the government should launch a national campaign "to inform the populace of the hazards of excessive sugar consumption." But the committee stood by its conclusions in the final version [59] of its report presented to the FDA in October 1976.

 

For the sugar industry, the report was gospel. The findings "should be memorized" by the staff of every company associated with the sugar industry, Tatem told his membership [57]. "In the long run," he said [60], the document "cannot be sidetracked, and you may be sure we will push its exposure to all corners of the country."

The association promptly produced an ad for newspapers and magazines exclaiming "Sugar is Safe!" It "does not cause death-dealing diseases," the ad declared, and "there is no substantiated scientific evidence indicating that sugar causes diabetes, heart disease or any other malady...The next time you hear a promoter attacking sugar, beware the ripoff. Remember he can't substantiate his charges. Ask yourself what he's promoting or what he is seeking to cover up. If you get a chance, ask him about the GRAS Review Report. Odds are you won't get an answer. Nothing stings a nutritional liar like scientific facts."

THE SUGAR ASSOCIATION WOULD SOON get its chance to put the committee's sugar review to the test. In 1977, McGovern's select committee—the one that had held the 1973 hearings on sugar and diabetes—blindsided the industry with a report titled "Dietary Goals for the United States," recommending that Americans lower their sugar intake by 40 percent(PDF) [61]. The association "hammered away" at the McGovern report using the GRAS review "as our scientific Bible," Tatem told sugar executives [62].

McGovern held fast, but Big Sugar would prevail in the end. In 1980, when the USDA first published [63] its own set of dietary guidelines, it relied heavily [64] on a review written for the American Society of Clinical Nutrition by none other than Bierman [65], who used the GRAS committee's findings to bolster his own. "Contrary to widespread opinion, too much sugar does not seem to cause diabetes," the USDA guidelines concluded. They went on to counsel that people should "avoid too much sugar," without bothering to explain what that meant.

In 1982, the FDA once again took up the GRAS committee's conclusion that sugar was safe, proposing to make it official. The announcement resulted in a swarm of public criticism, prompting the agency to reopen its case. Four years later, an agency task force concluded [66], again leaning on industry-sponsored studies, that "there is no conclusive evidence...that demonstrates a hazard to the general public when sugars are consumed at the levels that are now current." (Walter Glinsmann, the task force's lead administrator, would later become aconsultant [67] to the Corn Refiners Association, which represents producers of high-fructose corn syrup.)

The USDA, meanwhile, had updated its own dietary guidelines. With Fred Stare now on the advisory committee, the 1985 guidelines [68] retained the previous edition's vague recommendation to "avoid too much" sugar but stated unambiguously that "too much sugar in your diet does not cause diabetes." At the time, the USDA's own Carbohydrate Nutrition Laboratory was still generating evidence [69] to the contrary and supporting the notion that "even low sucrose intake" might be contributing to heart disease in 10 percent of Americans.

By the early 1990s, the USDA's research into sugar's health effects had ceased, and the FDA's take on sugar had become conventional wisdom, influencing a generation's worth of key publications on diet and health. Reports from the surgeon general [70] and the National Academy of Sciences [71] repeated the mantra that the evidence linking sugar to chronic disease was inconclusive, and then went on to equate "inconclusive" with "nonexistent." They also ignored a crucial caveat: The FDA reviewers had deemed added sugars—those in excess of what occurs naturally in our diets—safe at "current" 1986 consumption levels. But the FDA's consumption estimate was 43 percent lower than that of its sister agency, the USDA. By 1999, the average American would be eating more than double the amount [13] the FDA had deemed safe­—although we have cut back by 13 percent since then.

 

ASKED TO COMMENT ON SOME of the documents described in this article, a Sugar Association spokeswoman responded that they are "at this point historical in nature and do not necessarily reflect the current mission or function" of the association. But it is clear enough that the industry still operates behind the scenes to make sure regulators never officially set a limit on the amount of sugar Americans can safely consume. The authors of the 2010 USDA dietary guidelines, for instance, cited two scientific reviews [72] as evidence that sugary drinks don't make adults fat. The first was written by Sigrid Gibson [73], a nutrition consultant whose clients included the Sugar Bureau (England's version of the Sugar Association) and the World Sugar Research Organization (formerly the ISRF). The second review was authored by Carrie Ruxton [74], who served as research manager of the Sugar Bureau from 1995 to 2000.

The Sugar Association has also worked its connections to assure that the government panels making dietary recommendations—the USDA's Dietary Guidelines Advisory Committee, for instance—include researchers sympathetic to its position. One internal newsletter[75] boasted in 2003 that for the USDA panel, the association had "worked diligently to achieve the nomination of another expert wholly through third-party endorsements."

 

In the few instances when governmental authorities have sought to reduce people's sugar consumption, the industry has attacked openly. In 2003, after an expert panel convened by the World Health Organization recommended that no more than 10 percent of all calories in people's diets should come from added sugars—nearly 40 percent less than the USDA's estimate [76] for the average American—current Sugar Association president Andrew Briscoe wrote [77] the WHO's director general warning that the association would "exercise every avenue available to expose the dubious nature" of the report and urge "congressional appropriators to challenge future funding" for the WHO. Larry Craig (R-Idaho, sugar beets) and John Breaux (D-La., sugarcane), then co-chairs of the Senate Sweetener Caucus, wrote a letter [78] to Secretary of Health and Human Services Tommy Thompson, urging his "prompt and favorable attention" to prevent the report from becoming official WHO policy. (Craig had received more than $36,000 [79] in sugar industry contributions in the previous election cycle.) Thompson's people responded with a 28-page letter [80] detailing "where the US Government's policy recommendations and interpretation of the science differ" with the WHO report. Not surprisingly, the organization left its experts' recommendation on sugar intake out of itsofficial dietary strategy [81].

In recent years the scientific tide has begun to turn against sugar. Despite the industry's best efforts, researchers and public health authorities have come to accept that the primary risk factor for both heart disease and type 2 diabetes is a condition called metabolic syndrome, which now affects more than 75 million Americans [82], according to the Centers for Disease Control and Prevention. Metabolic syndrome [83] is characterized by a cluster of abnormalities—some of which Yudkin and others associated with sugar almost 50 years ago—including weight gain, increased insulin levels, and elevated triglycerides. It also has been linked tocancer [84] and Alzheimer's disease [85]. "Scientists have now established causation," Lustig said recently. "Sugar causes metabolic syndrome."

 

Newer studies [86] from the University of California-Davis have even reported that LDL cholesterol, the classic risk factor for heart disease, can be raised significantly in just two weeksby drinking sugary beverages at a rate well within the upper range of what Americans consume—four 12-ounce glasses a day of beverages like soda, Snapple, or Red Bull. The result is a new wave of researchers coming out publicly against Big Sugar.

During the battle over the 2005 USDA guidelines, an internal Sugar Association newsletter [87] described its strategy toward anyone who had the temerity to link sugar consumption with chronic disease and premature death: "Any disparagement of sugar," it read, "will be met with forceful, strategic public comments and the supporting science." But since the latest science is anything but supportive of the industry, what happens next?

"At present," Lustig ventures, "they have absolutely no reason to alter any of their practices. The science is in—the medical and economic problems with excessive sugar consumption are clear. But the industry is going to fight tooth and nail to prevent that science from translating into public policy."

Like the tobacco industry before it, the sugar industry may be facing the inexorable exposure of its product as a killer—science will ultimately settle the matter one way or the other—but as Big Tobacco learned a long time ago, even the inexorable can be held up for a very long time.

http://www.motherjones.com/toc/2012/11

Friday
Nov162012

1930s medicine pushes Europe back into double-dip recession

The Dutch economy shrank by 1.1pc in the third quarter amid a deep housing slump, and even Austria has begun to succumb. Finland’s economy has shrunk by 1pc over the last year.

“Recession comes as no surprise and it is going to get worse next year,” said Desmond Supple from Nomura. “Europe has imposed dusted-off policies from the 1930s and they are driving peripheral countries towards depression,” he said.

“We are seeing a mix of pro-cyclical fiscal austerity, overly-tight monetary policy, and regulatory overkill under the Basel III bank rules that are forcing lenders to tighten credit. Europe is stuck in a bad equilibrium and it is not going to end until there is a change of course.”

Prof Paul de Grauwe from the London School of Economics (LSE) said austerity measures imposed on the Club Med with no offsetting stimulus by the creditors was creating a contractionary bias to the whole system and and leading to a “very dangerous situation”.

France managed to stave off recession by the skin of its teeth, but that is unlikely to last after a blizzard of grim data in recent weeks and an austerity shock of 2pc of GDP coming next year.

Howard Archer from IHS Global Insight said the entire core would soon be engulfed. “Germany looks to be in severe danger of contracting in the fourth quarter, as does France,” he said.

Mario Draghi, the European Central Bank’s president, warned Europe’s leaders not to sit on their hands thinking that the ECB has solved the crisis for them with its €1 trillion (£805bn) lending blitz to banks and its pledge to backstop Spain and Italy – once these countries request a rescue and give up fiscal sovereignty.

“We have been able to steady the course. We have gained precious time, but this is not infinite,” he said. The comments were seen as warning to Spain to stop dragging its feet over a bail-out. Belgium’s ECB governor, Luc Coene, was explicit, saying Spain must trigger the mechanism “urgently”.

Spanish premier Mariano Rajoy has said he will hold back unless borrowing costs surge to unbearable levels. The mere threat of ECB action has calmed markets enough so far to let Spain cover its funding needs into 2013, but this may be a fragile truce.

On Thursday, Mr Rajoy suspended the eviction of families with children and other vulnerable groups that default on mortgages as an “emergency response” following a suicide that stunned the country, disregarding EU demands for action to clear a backlog of arrears.

The Spanish daily El Confidencial said Mr Rajoy is exploring plans for a rescue from the International Monetary Fund, circumventing the EU altogether – a claim denied by Madrid.

The newspaper said Mr Rajoy and his advisers fear that the German, Dutch, and Finnish parliaments may block a rescue or impose intolerable terms. They also believe that France will be sucked into the maelstrom before long as its own dire problems come the surface, changing the political dynamic in Europe.

Prof Luis Garicano from the LSE said it would be an “outstanding idea” for Spain to break free of EU austerity diktats and seek a neutral umpire. “The IMF has been on the side of reason, whereas the EU has been behaving like a creditor trying to get its money back.”

Prof Garicano said Spain was “betrayed” over the EU bail-out for its banks in July. Mr Rajoy was told the eurozone rescue fund (ESM) would able to clean up Spanish lenders directly once a pan-EMU supervisor was in place, lifting the burden from the Spanish state. Madrid accepted stringent terms on this understanding, only to be told later that “legacy” costs would not in fact be covered.

“There is now a lack of trust. They don’t really believe the EU will deliver on promises. But it is a dangerous game to postpone a full rescue until Spain has already failed,” he said.

Mr Rajoy may have been emboldened after US President Barack Obama said “Spain cannot be allowed to fail”. But diplomats say the IMF would balk at a direct request, seen as a ploy to be playing off Washington against Berlin.

The US, Canada, China, Japan, Brazil and others on the IMF board say Europe has the wealth to sort out its own crisis, which is entirely self-created by the internal mechanisms of EMU.

The Centre for Economic Policy Research said the eurozone has been in continuous recession since the autumn of 2011 using a wide array of output and jobs data tracked by its Business Cycle Dating Committee. Unemployment has climbed to a euro-era high of 11.6pc for the whole currency bloc, reaching 25.8pc in Spain and 25pc in Greece.

There is no relief in sight. The broad M3 money supply for the eurozone contracted over the last two months and is signalling further trouble next year. The ECB’s latest loan survey showed a collapse in credit demand of almost 50pc in Italy and France.

http://www.telegraph.co.uk/finance/financialcrisis/9681868/1930s-medicine-pushes-Europe-back-into-double-dip-recession.html

Wednesday
Nov142012

Rise of the Bacterial Superbug: Systemic Misuse of Antibiotics to Blame

A new health report shows that bacterial superbugs are on the rise while health and consumer advocacy groups blame overuse among both humans and livestock as the root cause.

Research by international NGO, Center for Disease Dynamics, Economics & Policy, found that "residents of Appalachian and Gulf Coast states, where antibiotic use rates are highest, take about twice as many antibiotics per capita as people living in Western states." States where usage is highest include Kentucky, West Virginia, Tennessee, Mississippi, and Louisiana.

Reporting on the research USA Today adds that, despite findings that overall prescription antibiotic use among patients in the US has dropped 17% since 1999, misuse of the drugs has grown:

Drugs for many bacterial infections are becoming ineffective because they are so often taken when they are not needed—allowing bugs that cause everything from pneumonia to sexually transmitted diseases to adapt and survive future attempts at treatment. Much of the overuse is for colds, flu and sore throats caused by viruses—illnesses that antibiotics can't help.

The report is one of several being released as part of the Center For Disease Control and Prevention's "Get Smart About Antibiotics Week" November 12-18, during which physicians and health organizations call attention to the abuse and growing impotence of valuable medicine.

One troubling example of this, according to research by the CDDEP, is "certain types of bacteria responsible for causing urinary tract infections (UTIs), the second-most-common infection in the United States, are becoming more difficult to treat with current antibiotics…with the overall share of resistant bacteria increasing by over 30% between 1999 and 2010."

The report found that the "burden of antibiotic resistance for urinary tract infections was highest in the Southeast states" where research has indenfitifed these regions as "the most intensive users of antibiotics." They write that this overuse "likely speeds up the development of resistant strains of the bacteria causing these and other more serious infections."

In a related action, the Consumers Union—the policy and advocacy arm of Consumer Reports—made a statement on Monday calling for a major reduction in the use of antibiotics in food animal production blaming overuse for the promotion and spread of drug-resistant superbugs.

"It's time to stop the daily feeding of antibiotics to healthy food animals which makes these life-saving medications less effective for people," Jean Halloran, director of food policy initiatives for Consumers Union, announced in a press release.

The statement continues:

Some 80 percent of all antibiotics sold in the U.S. are used on food animals, mostly to make them grow faster or prevent disease in crowded and unsanitary conditions. As a result of large scale use of antibiotics in livestock production, most of the bugs that are vulnerable to the antibiotics are eventually killed off, leaving behind superbugs that are immune to one or more of the drugs. These superbugs spread on the farm and beyond, contributing to antibiotic resistance in hospitals and our communities.

Numerous health organizations, including the American Medical Association, American Public Health Association, Infectious Disease Society of America, and the World Health Organization, agree that there is "strong evidence of a link between antibiotic use in food animals and antibiotic resistance in humans," and have called for significant reductions in the use of antibiotics for animal food production.

http://www.commondreams.org/headline/2012/11/13-4

Wednesday
Nov142012

Research suggests that humans are slowly but surely losing intellectual and emotional abilities

Human intelligence and behavior require optimal functioning of a large number of genes, which requires enormous evolutionary pressures to maintain. A provocative hypothesis published in a recent set of Science and Society pieces published in the Cell Press journal Trends in Genetics suggests that we are losing our intellectual and emotional capabilities because the intricate web of genes endowing us with our brain power is particularly susceptible to mutations and that these mutations are not being selected against in our modern society.

"The development of our intellectual abilities and the optimization of thousands of intelligence genes probably occurred in relatively non-verbal, dispersed groups of peoples before our ancestors emerged from Africa," says the papers' author, Dr. Gerald Crabtree, of Stanford University. In this environment, intelligence was critical for survival, and there was likely to be immense selective pressure acting on the genes required for intellectual development, leading to a peak in human intelligence.

From that point, it's likely that we began to slowly lose ground. With the development of agriculture, came urbanization, which may have weakened the power of selection to weed out mutations leading to intellectual disabilities. Based on calculations of the frequency with which deleterious mutations appear in the human genome and the assumption that 2000 to 5000 genes are required for intellectual ability, Dr. Crabtree estimates that within 3000 years (about 120 generations) we have all sustained two or more mutations harmful to our intellectual or emotional stability. Moreover, recent findings from neuroscience suggest that genes involved in brain function are uniquely susceptible to mutations. Dr. Crabtree argues that the combination of less selective pressure and the large number of easily affected genes is eroding our intellectual and emotional capabilities.

But not to worry. The loss is quite slow, and judging by society's rapid pace of discovery and advancement, future technologies are bound to reveal solutions to the problem. "I think we will know each of the millions of human mutations that can compromise our intellectual function and how each of these mutations interact with each other and other processes as well as environmental influences," says Dr. Crabtree. "At that time, we may be able to magically correct any mutation that has occurred in all cells of any organism at any developmental stage. Thus, the brutish process of natural selection will be unnecessary."

http://www.eurekalert.org/pub_releases/2012-11/cp-rst110912.php